Wnt3a mediated activation of Wnt/β-catenin signalling promotes tumor progression in glioblastoma.

Wnt3a mediated activation of Wnt/β-catenin signalling promotes tumor progression in glioblastoma.

Authors: Kaur N, Chettiar S, Rathod S, Rath P, Mujumdar D, Shaikh M, Shiras A Abstract Presence of a distinct population of cells that drives tumor progression supports the hierarchical model of tumor development in Glioblastoma (GBM) and substantiates the cancer stem cell hypothesis. Amongst the various developmental signalling pathways that are aberrantly activated, we here show that activated Wnt /β-catenin signalling pathway plays a critical role in malignant transformation and tumor progression in gliomas. We demonstrate that Wnt ligands - Wnt1 and Wnt3a are expressed in a graded manner in these tumors as well as over-expressed in glioma stem cell-lines. A selective inhibition of Wnt signalling pathway by selective knock-down of its ligands Wnt1 and Wnt3a in glioma-derived st... View Source