Upregulation of DLX2 confers a poor prognosis in glioblastoma patients by inducing a proliferative phenotype.
Authors: Yan ZH, Bao ZS, Yan W, Liu YW, Zhang CB, Wang HJ, Feng Y, Wang YZ, Zhang W, You G, Zhang QG, Jiang T
Abstract
The human Distal-less Homeobox (DLX) gene family encodes homeobox transcription factors involved in the control of morphogenesis and tissue homeostasis, which is primarily expressed in embryonic development. Recently, DLX gene family was reported to have essential roles in carcinogenesis. We have profiled whole genome expressed genes in 83 glioblastoma multiforme (GBM) patients from the Chinese Glioma Genome Atlas (CGGA) Group. Two major groups of samples were identified in mRNA expression profiles (referred to as Group 1 (G1) and Group 2 (G2)). We identified 7 out of the top 10 Gene Ontology terms in the G1 group were associated with differentiation and developmen...
