Response of Connexin-43 to Estradiol: A Predictive Factor for the Therapy of Glioma? (P02.163)
CONCLUSIONS: Over-expression of Cx43 has inverse association with the grade of glioma. Therefore, increasing the expression of Cx43 can be beneficial for the treatment of glioma. We showed that, Cx43 is differentially modulated in two different glioma cell lines in response to Es. We also showed that microglia has critical impact in this regulation. In conclusion, we suggest Cx43 as a predictive factor for the response to Es antagonist. We recommend further in vivo investigation of the role of Es and its antagonist on Cx43.Supported by: International Graduate School of Neuroscience.Disclosure: Dr. Moinfar has nothing to disclose. Dr. Dambach has nothing to disclose. Dr. Babady has nothing to disclose. Dr. Gold has received personal compensation for activities with Bayer HealthCare, Biogen ...
