Phospho‐Ser383‐Elk‐1 is localized to the mitotic spindles during cell cycle and interacts with mitotic kinase Aurora‐A
Elk‐1 is a member of the E‐twenty‐six (ETS) domain superfamily of transcription factors and has been traditionally associated with mitogen‐induced immediate early gene transcription upon phosphorylation by mitogen activated protein kinases (ERK/MAPK). Elk‐1 is not only upregulated but also phosphorylated in brain tumour cells. However, in this study, we show for the first time that S383‐phosphorylated Elk‐1 (P‐S383‐Elk‐1) is associated with mitotic spindle poles from metaphase through telophase and relocates to the spindle midbody during cytokinesis, while Thr417Ala mutation is associated with DNA throughout mitosis. Serine 383 phosphorylation appears to be important for polar localization of Elk‐1, since exogenous protein including serine‐to‐alanine mutation was ...
