Liposomes Modified with P-Aminophenyl-α-D-Mannopyranoside: A Carrier for Targeting Cerebral Functional Regions in Mice.

Liposomes Modified with P-Aminophenyl-α-D-Mannopyranoside: A Carrier for Targeting Cerebral Functional Regions in Mice.

Authors: Hao ZF, Cui YX, Li MH, Du D, Liu MF, Tao HQ, Li S, Cao FY, Chen YL, Lei XH, Wang L, Zhu DL, Jiang CL, Peng HS Abstract Targeting of intracerebral functional regions has been limited by the inability to transport drugs across the blood-brain barrier (BBB) and by poor accumulation in these regions. To overcome these hurdles, liposomes modified with P-Aminophenyl-α-D-Mannopyranoside (MAN) were used as a fluorescent dye carrier through the BBB and used the specific distribution of liposomes (LIP) modified with MAN (MAN-LIP) to target various functional regions of the brain. An in vitro BBB model was established to evaluate the transendothelial ability of MAN-LIP, and liposomes uptake by C6 glioma cells was analyzed by flow cytometry and live cell imaging. Liposome targeting w... View Source