Assessment of the Changes in 9L and C6 Glioma pO(2) by EPR Oximetry as a Prognostic Indicator of Differential Response to Radiotherapy.

Assessment of the Changes in 9L and C6 Glioma pO(2) by EPR Oximetry as a Prognostic Indicator of Differential Response to Radiotherapy.

Authors: Hou H, Mupparaju SP, Lariviere JP, Hodge S, Gui J, Swartz HM, Khan N Abstract Tumor hypoxia impedes the outcome of radiotherapy. As the extent of hypoxia in solid tumors varies during the course of radiotherapy, methods that can provide repeated assessment of tumor pO(2) such as EPR oximetry may enhance the efficacy of radiotherapy by scheduling irradiations when the tumors are oxygenated. The repeated measurements of tumor pO(2) may also identify responders, and thereby facilitate the design of better treatment plans for nonresponding tumors. We have investigated the temporal changes in the ectopic 9L and C6 glioma pO(2) irradiated with single radiation doses less than 10 Gy by EPR oximetry. The therapeutic outcome was determined with and without the treatment of the subs... View Source