A role for LRIG1 in the regulation of malignant glioma aggressiveness.
Authors: Mao F, Wang B, Xiao Q, Xi G, Sun W, Zhang H, Ye F, Wan F, Guo D, Lei T, Chen X
Abstract
The molecular mechanisms that drive the develop-ment and aggressive progression of malignant astrocytic tumors remain obscure. Recently, in the search for endo-genous negative regulators of EGF receptor, LRIG1 was cloned and characterized as a putative tumor suppressor gene often downregulated in various human tumors, including astrocytic tumors. Although several studies have implicated the function of LRIG1 in the inhibition of tumorigenesis, its precise role and potential underlying mechanisms remain obscure. Therefore, we generated a full-length expression vector to overexpress LRIG1 in the U251 malignant glioma cell line. Introduction of exo...
