A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.

A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.

Conclusions The incidence of seizures after surgery for brain tumors is low (8% [95% CI 3%-18%]) even without prophylactic AEDs, and the incidence of clinically significant seizures is even lower (3%). In contrast, routine phenytoin administration is associated with significant drug-related morbidity. Although the lower-than-anticipated incidence of seizures in the control group significantly limited the power of the study, the low baseline rate of perioperative seizures in patients with brain tumors raises concerns about the routine use of prophylactic phenytoin in this patient population. PMID: 23394340 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery) View Source