CONCLUSIONS:Use of antithrombotic agents has reduced the rate of primary VTE, with minimal increases in bleeding risk in specific ambulatory cancer populations. Further investigation is needed to guide and narrow recommendations for primary VTE prophy…
View SourceStephanie Parr, 32, from Derbyshire, was forced to cancel her wedding to fiance Neil after she suffered a fit last April. She was later diagnosed with a tumour the size of a tennis ball. (Source: the Mail online | Health)
View SourceIn this study, miR-7 was applied in glioma treatment for the first time in vivo. Our findings suggested that the plasmid-mediated gene therapy with miR-7 appeared to be a promising candidate for the development of new antitumor and anti-metastasis treatment for human glioma. Keywords: miR-7, glioma, metastasis, apoptosis, gene therapy.
PMID: 23373996 [PubMed – as supplied by publisher] (Source: Neoplasma)
ConclusionsThe low overlap of dysregulated genes in AT/RTs and KRTs suggests that factors in addition to SMARCB1 loss play a role in determining subsequent gene expression. Drugs which target cell cycle or epigenetic genes may be useful in all RTs. Additionally, targeted therapies tailored to specific RT subset molecular profiles should be considered. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
View Source(Arizona State University) Brain tumor and brain injury research will be supported by new seed grant program established by Arizona State University and the Barrow Neurological Institute at Phoenix Children’s Hospital. The program seeks to support effo…
View SourceConclusion:
Everolimus therapy is safe and effective for longer term (median exposure 34.2 months) treatment of patients with TSC with SEGA.
Classification of evidence:
This study provides Class III evidence that everolimus, titrated to trough serum l…
CONCLUSIONS: The antitumor activity of this combination at the phase II dose tested was limited. Pharmacokinetic data indicated that exposure to lapatinib was subtherapeutic in the phase II evaluation. Evaluation of intratumoral drug delivery and activity may be essential for hypothesis-testing trials with targeted agents in malignant glioma. Clin Cancer Res; 19(4); 1-9. ©2012 AACR.
PMID: 23363814 [PubMed – as supplied by publisher] (Source: Clinical Cancer Research)
This report summarizes the clinical recommendations for the management of SEGA made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined.
PMID: 23391693 [PubMed – as supplied by publisher] (…
A 48-year-old woman was admitted with a 3-year history of intermittent dizziness and unstable gait. Cranial MRI demonstrated a laminated lesion of T2 hyperintensity and T1 hypointensity involving the left cerebellar hemisphere, which appeared enlarged …
View SourceConclusion: The cognitive ability and intelligence level of the patients significantly declined between on and off treatment periods, and higher intelligence functioning at both on and off treatment was correlated with long-term higher HRQOL. Further i…
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