In this study, we have developed an efficient stem cell based therapeutic strategy that simultaneously allows killing of tumor cells and assessment and eradication of SC post highly malignant glioblastoma multiforme (GBM) brain tumor treatment. Mesench…
View SourceConclusion:pCASL imaging may facilitate differentiation of high‐grade gliomas from lymphomas and prediction of EGFR expression status in high‐grade gliomas. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
View SourceDetection of remote neuronal reactions in the Thalamus and Hippocampus induced by rat glioma using the PET tracer cis-4-[18F]fluoro-D-proline
Journal of Cerebral Blood Flow & Metabolism advance online publication, February 6 2013.
doi:10.1038/jcbfm.2013.8
Authors: Stefanie Geisler, Antje Willuweit, Michael Schroeter, Karl Zilles, Kurt Hamacher, Norbert Galldiks, Nadim J Shah, Heinz H Coenen
& Karl-Josef Langen (Source: Journal of Cerebral Blood Flow)
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Conclusion:The ability to accurately identify changes in diffusion on traditional FDMs is confounded in areas where perfusion and diffusion changes are colocalized. Flow‐compensated FDMs, which use only non‐zero b‐values, should therefore be the standard approach. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
View SourceConclusion:LTKM with local AIF provides more accurate estimation of physiological parameters and improves discrimination between low‐grade and high‐grade gliomas as compared with GTKM. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
View SourceThis study investigated the merits of using a nano-sized, fluorescent, paramagnetic CEST MRI contrast agent for detecting gliomas. Nanomedicine (Source: Medscape Today Headlines)
View SourceResearchers have identified two molecules that could potentially serve as biomarkers in predicting brain metastases in patients with breast cancer.
View SourceCONCLUSIONS: These findings allow the identification of a subset of patients that will be responsive to c-MET inhibition, and propose ligand pre-treatment as a potential new strategy for improving the anti-cancer efficacy of RTK inhibitors.
PMID: 2…
Resistance of glioblastoma multiforme (GBM) to tumor necrosis factor (TNF) α-induced apoptosis have been attributed to increased nuclear factor-kappaB (NF-B) activation. As we have previously reported that certain anticancer chemotherapeutics can…
View SourceIn vitro and descriptive studies of human tissue samples revealed the pro‐coagulant glycoprotein tissue factor (TF) as a potent player in glioma cell infiltration that is activated by hypoxia and has also been shown to be upregulated by mutations of TP53 or PTEN. Here we present the morphological and genetic characterization of a novel glioblastoma in vivo model and provide evidence that treatment with an antibody targeting TF leads to reduced glioma cell invasiveness. Therefore, we established a murine xenograft treatment model by transplanting the angiogenic and diffusely infiltrating human glioma cell line MZ‐18 with endogenous TF expression into nude mice brains and treating these mice with an intracranial osmotic pump system continuously infusing a monoclonal antibody against TF (…
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