Detection of remote neuronal reactions in the Thalamus and Hippocampus induced by rat glioma using the PET tracer cis-4-[18F]fluoro-D-proline

Detection of remote neuronal reactions in the Thalamus and Hippocampus induced by rat glioma using the PET tracer cis-4-[18F]fluoro-D-proline

Journal of Cerebral Blood Flow & Metabolism advance online publication, February 6 2013.
doi:10.1038/jcbfm.2013.8

Authors: Stefanie Geisler, Antje Willuweit, Michael Schroeter, Karl Zilles, Kurt Hamacher, Norbert Galldiks, Nadim J Shah, Heinz H Coenen
& Karl-Josef Langen (Source: Journal of Cerebral Blood Flow)

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Tumor blood flow from arterial spin labeling perfusion MRI: A key parameter in distinguishing high‐grade gliomas from primary cerebral lymphomas, and in predicting genetic biomarkers in high‐grade gliomas

Conclusion:pCASL imaging may facilitate differentiation of high‐grade gliomas from lymphomas and prediction of EGFR expression status in high‐grade gliomas. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)

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Molecular Pathways : Radiation-induced cognitive impairment.

Authors: Greene-Schloesser D, Moore E, Robbins ME
Abstract
Approximately 200,000/year in the US will receive partial or whole brain irradiation for the treatment of primary or metastatic brain cancer. Early and delayed radiation effects are transient and reversible with modern therapeutic standards; yet late radiation effects (≥6 months postirradiation) remain a significant risk, resulting in progressive cognitive impairment. These include functional deficits in memory, attention, and executive function that severely affect the patient’s quality of life (QOL). The mechanisms underlying radiation-induced cognitive impairment remain ill defined. Classically, radiation-induced alterations in vascular and glial cell clonogenic populations were hypothesized to be responsible for radi…

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Subcompartmentalization of extracellular extravascular space (EES) into permeability and leaky space with local arterial input function (AIF) results in improved discrimination between high‐ and low‐grade glioma using dynamic contrast‐enhanced (DCE) MRI

Conclusion:LTKM with local AIF provides more accurate estimation of physiological parameters and improves discrimination between low‐grade and high‐grade gliomas as compared with GTKM. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)

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Anti‐tissue factor (TF9‐10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model

In vitro and descriptive studies of human tissue samples revealed the pro‐coagulant glycoprotein tissue factor (TF) as a potent player in glioma cell infiltration that is activated by hypoxia and has also been shown to be upregulated by mutations of TP53 or PTEN. Here we present the morphological and genetic characterization of a novel glioblastoma in vivo model and provide evidence that treatment with an antibody targeting TF leads to reduced glioma cell invasiveness. Therefore, we established a murine xenograft treatment model by transplanting the angiogenic and diffusely infiltrating human glioma cell line MZ‐18 with endogenous TF expression into nude mice brains and treating these mice with an intracranial osmotic pump system continuously infusing a monoclonal antibody against TF (…

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