Primary Cerebral Angioimmunoblastic T-Cell Lymphoma [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
View SourceA prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.
Conclusions The incidence of seizures after surgery for brain tumors is low (8% [95% CI 3%-18%]) even without prophylactic AEDs, and the incidence of clinically significant seizures is even lower (3%). In contrast, routine phenytoin administration is …
View SourceDAI provides potential imaging biomarker to indicate brain tumor response to RT
(American Society for Radiation Oncology) Diffusion abnormality index (DAI) shows promise as an imaging biomarker to measure brain tumor response to radiation therapy, according to research being presented at the 2013 Cancer Imaging and Radiation Thera…
View SourceSubcortical damage is ‘primary cause’ of neurological deficits after ‘awake craniotomy’
(Wolters Kluwer Health) Injury to the subcortical structures of the inner brain is a major contributor to worsening neurological abnormalities after “awake craniotomy” for brain tumors, reports a study in the February issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. (Source: EurekAlert! – Medicine and Health)
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Overcoming resistance to rapalogs in gliomas by combinatory therapies.
Authors: Grzmil M, Hemmings BA
Abstract
Glioblastoma is the most common and aggressive brain tumor type, with a mean patient survival of approximately 1year. Many previous analyses of the glioma kinome have identified key deregulated pathways t…
The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada
AimTo determine the epidemiology of chronic ataxia in children in Manitoba, Canada.
MethodA retrospective study using multiple sources and disease codes identified children (age 0–16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children’s Hospital from 1991 to 2008. Patients with isolated peripheral nerve diseases, vestibular disorders, or brain tumors were excluded.
ResultsWe identified 184 patients (males=females; mean age 15y, SD 7y 8mo) with chronic ataxia. Median age at the presenting symptom onset was 1 year 3 months and at ataxia onset 3 years 1 month. Median duration of follow‐up was 6 years 5 months. During the study period, the crude incidence rate was 5.77 in 10 000; the crude prevalence rate was 6.59 in 10 000; and the cr…
Assessment of the Changes in 9L and C6 Glioma pO(2) by EPR Oximetry as a Prognostic Indicator of Differential Response to Radiotherapy.
Authors: Hou H, Mupparaju SP, Lariviere JP, Hodge S, Gui J, Swartz HM, Khan N
Abstract
Tumor hypoxia impedes the outcome of radiotherapy. As the extent of hypoxia in solid tumors varies during the course of radiotherapy, methods that can provid…
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies
This study demonstrates that NVU regulation can be investigated using OHCs. We observed in this model system an increase in vascularization and a down-regulation of TJ proteins, similar to the vascular changes described in a chronic focus of epileptic …
View SourceCompound stimulates tumor-fighting protein in cancer therapy
A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers.
View SourceIn vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors.
In this study, we have developed an efficient stem cell based therapeutic strategy that simultaneously allows killing of tumor cells and assessment and eradication of SC post highly malignant glioblastoma multiforme (GBM) brain tumor treatment. Mesench…
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